the inn

Experience luxury accommodations in the heart of Historic Madison, Indiana.  Step back in time as you enter the beautiful Federal Italiante home, now run as 2 Sisters Bed & Breakfast.   

"bed and breakfast", "B&B in Madison, IN", 2 Sisters

2 Sisters Bed & Breakfast, owned by sisters Mary and Madonna, was built in 1840 in the Federal architectural style first adopted by wealthy merchants in New England. Well over 400 Federal style buildings grace the Historic District of Madison.

Future additions to the home took on the popular  post-Civil War styles of Italianate and Gothic Revival architecture.


In the late 1800s, the home was purchased by Julius and Fannie Hoffstadt, one of the first Jewish families to migrate to Madison.  Julius and his brother owned two businesses on Main Street with over 30 employees.


Their granddaughter, Rachel, earned a doctor of philosophy from the University of Chicago and a doctor of science from John Hopkins University.  She was the first Hanover College graduate to receive a doctorate.  While teaching at the University of Washington, Seattle, she was an early investigator in the use of oral vaccines for the treatment of typhoid fever 


Over the years, the house has been many things, but it has never lost the original charm. And now, with its grand stairwell, spacious front parlor and uniquely historical artwork,  we present it to you in its latest transformation, as 2 Sisters Bed & Breakfast, including all the modern necessities and features to accommodate guests in comfort and style.